2. Academic Validation
  3. Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2547-50. doi: 10.1016/j.bmcl.2004.02.087.
Yun-Hua Fan 1,  Han Chen,  Amarnath Natarajan,  Yuhong Guo,  Fred Harbinski,  Julia Iyasere,  William Christ,  Huseyin Aktas,  Jose A Halperin
Affiliations

Affiliation

  • 1 Laboratory for Translational Research, Harvard Medical School, Cambridge, MA 02139, USA. yunhuafan@yahoo.com
PMID: 15109648 DOI: 10.1016/j.bmcl.2004.02.087
Abstract

Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The Anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition of translation initiation. The unsaturated form of troglitazone displays similar Anticancer properties in vitro. In this letter, we report our findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities.

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