2. Academic Validation
  3. Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens

Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens

  • J Nat Prod. 2004 May;67(5):902-4. doi: 10.1021/np0400048.
Cláudia Valente 1,  Madalena Pedro,  Aida Duarte,  Maria São José Nascimento,  Pedro M Abreu,  Maria-José U Ferreira
Affiliations

Affiliation

  • 1 CECF, Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia da Universidade de Lisboa, Avenida das Forças Armadas, 1600-083 Lisboa, Portugal.
PMID: 15165162 DOI: 10.1021/np0400048
Abstract

A new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant Antibacterial activity against Staphylococcus aureus.

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