2. Academic Validation
  3. Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents

Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents

  • Bioorg Med Chem Lett. 2004 Jul 5;14(13):3517-20. doi: 10.1016/j.bmcl.2004.04.067.
Kenneth L Smith 1,  Vicky C H Lai,  Brett J Prigaro,  Yili Ding,  Esmir Gunic,  Jean-Luc Girardet,  Weidong Zhong,  Zhi Hong,  Stanley Lang,  Haoyun An
Affiliations

Affiliation

  • 1 Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA.
PMID: 15177464 DOI: 10.1016/j.bmcl.2004.04.067
Abstract

Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.

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