2. Academic Validation
  3. Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):3865-8. doi: 10.1016/j.bmcl.2004.05.073.
Timothy A Blizzard 1,  Frank DiNinno,  Jerry D Morgan 2nd,  Jane Y Wu,  Helen Y Chen,  Seongkon Kim,  Wanda Chan,  Elizabeth T Birzin,  Yi Tien Yang,  Lee-Yuh Pai,  Zhoupeng Zhang,  Edward C Hayes,  Carolyn A DaSilva,  Wei Tang,  Susan P Rohrer,  James M Schaeffer,  Milton L Hammond
Affiliations

Affiliation

  • 1 Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
PMID: 15225686 DOI: 10.1016/j.bmcl.2004.05.073
Abstract

A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.

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