2. Academic Validation
  3. Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):3957-62. doi: 10.1016/j.bmcl.2004.05.048.
Yingchun Lu 1,  Sukumar Sakamuri,  Quin-Zene Chen,  Yen-Fang Keng,  Vladimir Khazak,  Katrin Illgen,  Silke Schabbert,  Lutz Weber,  Sanjay R Menon
Affiliations

Affiliation

  • 1 Morphochem Inc., 11 Deer Park Drive, Suite 116, Monmouth Junction, NJ 08852, USA.
PMID: 15225706 DOI: 10.1016/j.bmcl.2004.05.048
Abstract

A solution phase parallel synthesis approach was undertaken to rapidly explore the structure-activity relationship of an inhibitor of the Ras/Raf protein interaction identified from a small molecule compound library. Evaluation of the MAPK pathway signaling inhibitory activity of the synthesized analogues as well as their antiproliferative activity and ability to inhibit soft agar growth were performed.

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