2. Academic Validation
  3. Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin

Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):4023-6. doi: 10.1016/j.bmcl.2004.05.032.
Yuan-gang Zu 1,  Qing-yong Li,  Yu-jie Fu,  Wei Wang
Affiliations

Affiliation

  • 1 Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, Harbin 150040, China. zygorl@public.hr.hl.cn
PMID: 15225719 DOI: 10.1016/j.bmcl.2004.05.032
Abstract

In an effort to improve the water solubility of camptothecin, 16 water soluble 10-substituted quaternary ammonium salt derivatives of camptothecin were prepared. Their antitumor activity was evaluated on Cancer cells in vitro. All of these salts possess lower cytotoxicities than CPT in comparison. The camptothecin salts 16, 20 showed similar cytotoxic activity to topotecan. Especially the salts 21 showed similar cytotoxic activity to CPT in vitro.

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