2. Academic Validation
  3. Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro

Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro

  • J Nat Prod. 2004 Jul;67(7):1193-6. doi: 10.1021/np0498915.
Cristina Moiteiro 1,  César Manta,  Fátima Justino,  Regina Tavares,  Maria João M Curto,  Madalena Pedro,  Maria São José Nascimento,  Madalena Pinto
Affiliations

Affiliation

  • 1 INETI, Instituto Nacional de Engenharia, Tecnologia e Inovação, Estrada do Paço do Lumiar, 1649-038 Lisbon, Portugal. cristina.moiteiro@ineti.pt
PMID: 15270581 DOI: 10.1021/np0498915
Abstract

Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane Triterpenes were synthesized stereoselectively in high yields. Compounds 5-9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung Cancer), and SF-268 (CNS Cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI(50) values that range from 24.6 to 32.8 microM and 10.9 to 17.6 microM, respectively.

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