2. Academic Validation
  3. P-Rex2, a new guanine-nucleotide exchange factor for Rac

P-Rex2, a new guanine-nucleotide exchange factor for Rac

  • FEBS Lett. 2004 Aug 13;572(1-3):172-6. doi: 10.1016/j.febslet.2004.06.096.
Sarah Donald 1,  Kirsti Hill,  Charlotte Lecureuil,  Romain Barnouin,  Sonja Krugmann,  W John Coadwell,  Simon R Andrews,  Simon A Walker,  Phillip T Hawkins,  Len R Stephens,  Heidi C E Welch
Affiliations

Affiliation

  • 1 Signalling Programme, Inositide Laboratory, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.
PMID: 15304343 DOI: 10.1016/j.febslet.2004.06.096
Abstract

We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It has widespread tissue distribution but is not expressed in neutrophils. P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate and the beta gamma subunits of heterotrimeric G proteins in vitro and in vivo. P-Rex2 has structure, activity and regulatory properties similar to P-Rex1 but has divergent tissue distribution, as P-Rex1 is mainly expressed in neutrophils. Together, they form an Enzyme family capable of mediating Rac signalling downstream of G protein-coupled receptors and phosphoinositide 3-kinase.

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