2. Academic Validation
  3. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors

Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors

  • Planta Med. 2004 Oct;70(10):1011-4. doi: 10.1055/s-2004-832632.
Aurélie Urbain 1,  Andrew Marston,  Emerson Ferreira Queiroz,  Karine Ndjoko,  Kurt Hostettmann
Affiliations

Affiliation

  • 1 Laboratory of Pharmacognosy and Phytochemistry, Geneva-Lausanne School of Pharmacy, University of Lausanne, Lausanne, Switzerland.
PMID: 15490334 DOI: 10.1055/s-2004-832632
Abstract

In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four Xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this Enzyme assay.

Figures
Products