2. Academic Validation
  3. 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

  • Bioorg Med Chem Lett. 2004 Dec 6;14(23):5727-30. doi: 10.1016/j.bmcl.2004.09.057.
Flemming E Nielsen 1,  Palle Jacobsen,  Anne Worsaae,  Per O G Arkhammar,  Philip Wahl,  John Bondo Hansen
Affiliations

Affiliation

  • 1 Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark.
PMID: 15501029 DOI: 10.1016/j.bmcl.2004.09.057
Abstract

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated Insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.

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