2. Academic Validation
  3. The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

  • Biochem Biophys Res Commun. 2005 Jan 7;326(1):242-8. doi: 10.1016/j.bbrc.2004.11.016.
Hiroaki Suzuki 1,  Megumi Kurita,  Kiyohisa Mizumoto,  Masatsugu Moriyama,  Sadakazu Aiso,  Ikuo Nishimoto,  Masaaki Matsuoka
Affiliations

Affiliation

  • 1 Department of Pharmacology, KEIO University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582, Japan.
PMID: 15567177 DOI: 10.1016/j.bbrc.2004.11.016
Abstract

The ARF tumor suppressor gene antagonizes generation of various tumors. ARF-mediated tumor suppression occurs in a p53-independent manner as well as in a p53-dependent manner. We here demonstrate that BCL6 is a target of the ARF tumor suppressor. Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression. ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression.

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