2. Academic Validation
  3. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

  • J Nat Prod. 2004 Nov;67(11):1829-32. doi: 10.1021/np040069a.
An De Naeyer 1,  Wim Vanden Berghe,  Victoria Pocock,  Stuart Milligan,  Guy Haegeman,  Denis De Keukeleire
Affiliations

Affiliation

  • 1 Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.
PMID: 15568770 DOI: 10.1021/np040069a
Abstract

Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast Cancer cells in the sulforhodamine-B assay.

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