2. Academic Validation
  3. Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)

Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)

  • J Nat Prod. 2005 Jan;68(1):43-9. doi: 10.1021/np0499113.
Feng Zhao 1,  Yuki Watanabe,  Hajime Nozawa,  Akihiro Daikonnya,  Keiji Kondo,  Susumu Kitanaka
Affiliations

Affiliation

  • 1 Central Laboratories for Key Technology, Kirin Brewery Co., Ltd., Yokohama-shi, Kanagawa 236-0004, Japan.
PMID: 15679315 DOI: 10.1021/np0499113
Abstract

The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known prenylflavonoids (1-4) and a new prenylflavonoid (5), hulupinic acid (6), lupulone (7), and its six new derivatives (8-13) were isolated from the active fraction. The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined.

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