2. Academic Validation
  3. Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors

  • Bioorg Med Chem Lett. 2005 Mar 15;15(6):1693-5. doi: 10.1016/j.bmcl.2005.01.050.
Guy Falardeau 1,  Hugo Lachance,  Annie St-Pierre,  Constantin G Yannopoulos,  Marc Drouin,  Jean Bédard,  Laval Chan
Affiliations

Affiliation

  • 1 ViroChem Pharma Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7. gfalardeau@virochempharma.com
PMID: 15745823 DOI: 10.1016/j.bmcl.2005.01.050
Abstract

A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.

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