2. Academic Validation
  3. Molecular defects in the growth hormone-IGF axis

Molecular defects in the growth hormone-IGF axis

  • Indian J Pediatr. 2005 Feb;72(2):145-8. doi: 10.1007/BF02760700.
Joyce Lee 1,  Ram K Menon
Affiliations

Affiliation

  • 1 Division of Endocrinology, Department of Pediatrics, CS Mott Childrens Hospital, University of Michigan Health System, Ann Arbor, USA.
PMID: 15758538 DOI: 10.1007/BF02760700
Abstract

Many previously uncharacterized cases of poor growth in children, i.e. idiopathic short stature, are now attributable to genetic defects in the GH-IGF-1 axis. This paper will provide an overview of the clinical findings of patients identified with various genetic defects of the GH/IGF-1 axis with an emphasis on the more recently described syndromes.

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