2. Academic Validation
  3. Structure elucidation of cyasterone stereoisomers isolated from Cyathula officinalis

Structure elucidation of cyasterone stereoisomers isolated from Cyathula officinalis

  • Org Biomol Chem. 2005 Apr 7;3(7):1227-32. doi: 10.1039/b416868b.
Keiko Okuzumi 1,  Noriyuki Hara,  Hidehiro Uekusa,  Yoshinori Fujimoto
Affiliations

Affiliation

  • 1 Department of Chemistry and Materials Science, Tokyo Institute of Technology, Meguro, Tokyo 152-8551, Japan.
PMID: 15785811 DOI: 10.1039/b416868b
Abstract

Chemical investigation of ecdysteroidal constituents of the roots and stems of Cyathula officinalis led to the isolation of two cyasterone stereoisomers, 2 and 3, together with the known cyasterone 1. The structures of compounds 2 and 3 were determined to be 28-epi-cyasterone and 25-epi-28-epi-cyasterone, respectively, by means of spectroscopic analysis. X-Ray structures of 1 and 2 confirmed the 24S,25S,28R configuration for 1 and 24S,25S,28S for 2.

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