2. Academic Validation
  3. Bioactive benzophenones from Garcinia xanthochymus fruits

Bioactive benzophenones from Garcinia xanthochymus fruits

  • J Nat Prod. 2005 Mar;68(3):354-60. doi: 10.1021/np0497595.
Scott Baggett 1,  Petr Protiva,  Eugene P Mazzola,  Hui Yang,  Elizabeth T Ressler,  Margaret J Basile,  I Bernard Weinstein,  Edward J Kennelly
Affiliations

Affiliation

  • 1 Department of Biological Sciences, Lehman College and The Graduate School and University Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA.
PMID: 15787435 DOI: 10.1021/np0497595
Abstract

A MeOH extract of Garcinia xanthochymus fruits was subjected to activity-guided fractionation, yielding two new benzophenones, guttiferone H (1) and gambogenone (2). Compound 1 contains a seven-membered ring attached to the bicyclo[3.3.1]nonane system at positions 7 and 8 and displayed cytotoxicity in the SW-480 colon Cancer cell line (IC(50) = 12 microM). Compound 2 has a novel benzophenone bicyclo[3.3.2]decane system and displayed cytotoxicity in the SW-480 colon Cancer cell line (IC(50) = 188 microM). Both 1 and 2 induced Apoptosis in SW-480 colon Cancer cells and displayed antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (IC(50) = 64 and 38.7 microM, respectively). The structures of 1 and 2 were established by 1D and 2D NMR data analysis. Eleven known compounds, aristophenone A, alloathyriol, amentoflavone, 3,8' '-biapigenin, cycloxanthochymol, (+/-)-fukugetin, (+/-)-fukugiside, guttiferone E, isoxanthochymol, (+/-)-volkensiflavone, and xanthochymol, were also obtained. The 11 known compounds were also tested against SW-480 colon Cancer cells and in the DPPH assay.

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