2. Academic Validation
  3. The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery

  • Biochem J. 2005 Jul 1;389(Pt 1):13-7. doi: 10.1042/BJ20050211.
Ekaterina Smirnova 1,  Magali Toueille,  Enni Markkanen,  Ulrich Hübscher
Affiliations

Affiliation

  • 1 Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
PMID: 15871698 DOI: 10.1042/BJ20050211
Abstract

The human checkpoint sensor and alternative clamp Rad9-Rad1-Hus1 can interact with and specifically stimulate DNA Ligase I. The very recently described interactions of Rad9-Rad1-Hus1 with MutY DNA glycosylase, DNA Polymerase beta and Flap Endonuclease 1 now complete our view that the long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA.

Figures