2. Academic Validation
  3. N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

  • Bioorg Med Chem. 2005 Jul 15;13(14):4507-12. doi: 10.1016/j.bmc.2005.04.035.
Hitoshi Suda 1,  Akio Kobori,  Jinhua Zhang,  Gosuke Hayashi,  Kazuhiko Nakatani
Affiliations

Affiliation

  • 1 Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan.
PMID: 15916896 DOI: 10.1016/j.bmc.2005.04.035
Abstract

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.

Figures
Products