2. Academic Validation
  3. Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus

Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus

  • J Nat Prod. 2005 May;68(5):678-80. doi: 10.1021/np049688+.
Yin Tian 1,  Hongzhu Guo,  Jian Han,  Dean Guo
Affiliations

Affiliation

  • 1 The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road #38, Beijing 100083, People's Republic of China.
PMID: 15921408 DOI: 10.1021/np049688+
Abstract

Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells).

Figures