2. Academic Validation
  3. Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

Cytotoxic steroidal saponins from the rhizomes of Asparagus oligoclonos

  • J Nat Prod. 2005 May;68(5):766-8. doi: 10.1021/np040128k.
Geum-Soog Kim 1,  Hyun-Tae Kim,  Jae-Duck Seong,  Sei-Ryang Oh,  Chong-Ock Lee,  Jin-Ki Bang,  Nak-Sul Seong,  Kyung-Sik Song
Affiliations

Affiliation

  • 1 Ginseng & Medicinal Crops Division, National Institute of Crop Science (NICS), Rural Development Administration (RDA), Suwon 441-857, Korea.
PMID: 15921426 DOI: 10.1021/np040128k
Abstract

Two new steroidal saponins, aspaoligonins A (2) and B (3), were isolated from the methanolic extract of the rhizomes of Asparagus oligoclonos together with a known spirostanol saponin, asparanin A (1). Aspaoligonins A and B were characterized as (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-beta-D-glucopyranosyl (1-->2)-beta-D-glucopyranoside and (25S*)-5beta-spirostan-3beta,17alpha-diol 3-O-alpha-L-rhamnopyanosyl (1-->4)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranoside, respectively, by spectrometric analyses including HRFABMS and 2D NMR. Compounds 1-3 were cytotoxic against five human tumor cell lines with IC50 values of 2.05-2.84 microg/mL.

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