2. Academic Validation
  3. 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

  • Bioorg Med Chem Lett. 2005 Jul 15;15(14):3430-3. doi: 10.1016/j.bmcl.2005.05.012.
Raman K Bakshi 1,  Qingmei Hong,  J T Olson,  Zhixiong Ye,  Iyassue K Sebhat,  David H Weinberg,  Tanya MacNeil,  Rubana N Kalyani,  Rui Tang,  William J Martin,  Alison Strack,  Erin McGowan,  Constantin Tamvakopoulos,  Randy R Miller,  Ralph A Stearns,  Wei Tang,  D Euan Maclntyre,  Lex H T van der Ploeg,  Arthur A Patchett,  Ravi P Nargund
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com
PMID: 15951175 DOI: 10.1016/j.bmcl.2005.05.012
Abstract

The discovery of 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid analogs as potent human melanocortin-4 selective agonists is described.

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