2. Academic Validation
  3. Cytotoxic constituents of the fruit body of Daedalea dickisii

Cytotoxic constituents of the fruit body of Daedalea dickisii

  • J Nat Prod. 2005 Jun;68(6):911-4. doi: 10.1021/np058024c.
Kazuko Yoshikawa 1,  Kazuaki Kouso,  Jyoji Takahashi,  Akiko Matsuda,  Mina Okazoe,  Akemi Umeyama,  Shigenobu Arihara
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Japan. yosikawa@ph.bunri-r.ac.jp
PMID: 15974617 DOI: 10.1021/np058024c
Abstract

Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2-6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3-6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.

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