2. Academic Validation
  3. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3519-23. doi: 10.1016/j.bmcl.2005.05.096.
Douglas M Sammond 1,  Kristen E Nailor,  James M Veal,  Robert T Nolte,  Liping Wang,  Victoria B Knick,  Sharon K Rudolph,  Anne T Truesdale,  Eldridge N Nartey,  Jeffrey A Stafford,  Rakesh Kumar,  Mui Cheung
Affiliations

Affiliation

  • 1 GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. douglas.m.sammond@gsk.com
PMID: 15990302 DOI: 10.1016/j.bmcl.2005.05.096
Abstract

A series of dianilinopyrimidineureas demonstrate potency as VEGFR2/KDR/Flk-1 kinase inhibitors.

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