1. Academic Validation
  2. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3519-23. doi: 10.1016/j.bmcl.2005.05.096.
Douglas M Sammond 1 Kristen E Nailor James M Veal Robert T Nolte Liping Wang Victoria B Knick Sharon K Rudolph Anne T Truesdale Eldridge N Nartey Jeffrey A Stafford Rakesh Kumar Mui Cheung
Affiliations

Affiliation

  • 1 GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. douglas.m.sammond@gsk.com
Abstract

A series of dianilinopyrimidineureas demonstrate potency as VEGFR2/KDR/Flk-1 kinase inhibitors.

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