2. Academic Validation
  3. HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome

HRPT2, a tumor suppressor gene for hyperparathyroidism-jaw tumor syndrome

  • Horm Metab Res. 2005 Jun;37(6):380-3. doi: 10.1055/s-2005-870150.
P F Wang 1,  M-H Tan,  C Zhang,  H Morreau,  B T Teh
Affiliations

Affiliation

  • 1 Laboratory of Cancer Genetics, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
PMID: 16001331 DOI: 10.1055/s-2005-870150
Abstract

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from inactivating mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. Here, we will review recent advances in genetic and protein studies on parafibromin, and examine its biological functions.

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