2. Academic Validation
  3. 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?

3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?

  • J Nat Prod. 2005 Jul;68(7):1103-5. doi: 10.1021/np050036a.
Porntep Chomcheon 1,  Suthep Wiyakrutta,  Nongluksna Sriubolmas,  Nattaya Ngamrojanavanich,  Duangnate Isarangkul,  Prasat Kittakoop
Affiliations

Affiliation

  • 1 Program of Biotechnology and Department of Chemistry, Faculty of Science, Chulalongkorn University, Thailand.
PMID: 16038559 DOI: 10.1021/np050036a
Abstract

3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 microM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain Plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).

Figures
Products