2. Academic Validation
  3. Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica

Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica

  • Planta Med. 2005 Jul;71(7):646-53. doi: 10.1055/s-2005-871271.
Yao-Haur Kuo 1,  Ming-Der Wu,  Ray-Ling Huang,  Li-Ming Yang Kuo,  Ya-Wen Hsu,  Chia-Ching Liaw,  Chia-Cheng Hung,  Ya-Ching Shen,  Chi-Wi Ong
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C.
PMID: 16041651 DOI: 10.1055/s-2005-871271
Abstract

Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C18 dibenzocyclooctadiene Lignans, schizanrins I, J, K, L, M, N, along with four known C19 homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 microg/mL (12.9 and 11.9 microM for taiwanschirins A and B, respectively).

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