2. Academic Validation
  3. Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

Synthesis of doxorubicin-peptide conjugate with multidrug resistant tumor cell killing activity

  • Bioorg Med Chem Lett. 2005 Nov 15;15(22):5071-5. doi: 10.1016/j.bmcl.2005.07.087.
Jun F Liang 1,  Victor C Yang
Affiliations

Affiliation

  • 1 Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA. jliang2@stevens.edu
PMID: 16168650 DOI: 10.1016/j.bmcl.2005.07.087
Abstract

Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

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