2. Academic Validation
  3. Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines

Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines

  • J Nat Prod. 2005 Oct;68(10):1471-4. doi: 10.1021/np058044e.
Sung Ok Lee 1,  Sang Zin Choi,  Sang Un Choi,  Kang Choon Lee,  Young Won Chin,  Jinwoong Kim,  Young Choong Kim,  Kang Ro Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea, Korea Research Institute of Chemical Technology, Taejeon 305-600, Korea.
PMID: 16252909 DOI: 10.1021/np058044e
Abstract

Three new labdane diterpenes (1-3), together with eight known Diterpenoids, were isolated from a methanol extract of the aerial parts of Aster spathulifolius. The structures of 1-3 were determined as (13R)-labda-7,14-diene 13-O-beta-d-(4'-O-acetyl)fucopyranoside (1), (13R)-labda-7,14-diene 13-O-beta-d-(3'-O-acetyl)fucopyranoside (2), and (13R)-labda-14(15)-en-8,13-diol 13-O-beta-d-fucopyranoside (3), on the basis of spectroscopic and chemical methods. Compounds 1, 2, and four of the known compounds exhibited generally nonspecific cytotoxicity against human A549, SK-OV-3, SK-MEL-2, XF498, and HCT15 tumor cells.

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