2. Academic Validation
  3. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids

  • Chem Commun (Camb). 2005 Nov 21;(43):5438-40. doi: 10.1039/b510707e.
Biswadip Banerji 1,  Ana Conejo-Garcia,  Luke A McNeill,  Michael A McDonough,  Matthew R G Buck,  Kirsty S Hewitson,  Neil J Oldham,  Christopher J Schofield
Affiliations

Affiliation

  • 1 Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.
PMID: 16261239 DOI: 10.1039/b510707e
Abstract

Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.

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