2. Academic Validation
  3. Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

  • Bioorg Med Chem Lett. 2006 Jan 1;16(1):31-5. doi: 10.1016/j.bmcl.2005.09.058.
Patricia Melnyk 1,  Virginie Leroux,  Christian Sergheraert,  Philippe Grellier
Affiliations

Affiliation

  • 1 Institut de Biologie et Institut Pasteur de Lille, UMR CNRS 8525, Université de Lille II, 1 rue du Professeur Calmette, BP 447, 59021 Lille, France. patricia.melnyk@ibl.fr
PMID: 16263280 DOI: 10.1016/j.bmcl.2005.09.058
Abstract

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.

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