2. Academic Validation
  3. Structure elucidation of Sch 725674 from Aspergillus sp

Structure elucidation of Sch 725674 from Aspergillus sp

  • J Antibiot (Tokyo). 2005 Aug;58(8):535-8. doi: 10.1038/ja.2005.74.
Shu-Wei Yang 1,  Tze-Ming Chan,  Joseph Terracciano,  David Loebenberg,  Mahesh Patel,  Min Chu
Affiliations

Affiliation

  • 1 Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. shu-wei.yang@spcorp.com
PMID: 16266128 DOI: 10.1038/ja.2005.74
Abstract

A new Macrolide Sch725674 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was accomplished based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 32 microg/ml, respectively.

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