2. Academic Validation
  3. Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

  • Bioorg Med Chem Lett. 2006 Feb;16(3):668-71. doi: 10.1016/j.bmcl.2005.10.037.
Juliana Ruiz-Caro 1,  Aravind Basavapathruni,  Joseph T Kim,  Christopher M Bailey,  Ligong Wang,  Karen S Anderson,  Andrew D Hamilton,  William L Jorgensen
Affiliations

Affiliation

  • 1 Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.
PMID: 16298131 DOI: 10.1016/j.bmcl.2005.10.037
Abstract

Following computational analyses, potential non-nucleoside inhibitors of HIV-1 Reverse Transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het-NH-Ph-U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het=2-thiazoyl and 2-pyrimidinyl are the focus of this report.

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