2. Academic Validation
  3. Synthesis of deserpidine from reserpine

Synthesis of deserpidine from reserpine

  • J Nat Prod. 2005 Nov;68(11):1629-31. doi: 10.1021/np050179x.
Greta Varchi 1,  Arturo Battaglia,  Cristian Samorì,  Eleonora Baldelli,  Bruno Danieli,  Gabriele Fontana,  Andrea Guerrini,  Ezio Bombardelli
Affiliations

Affiliation

  • 1 Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy. G.Varchi@isof.cnr.it
PMID: 16309312 DOI: 10.1021/np050179x
Abstract

The Rauwolfia Alkaloids reserpine (1) and deserpidine (2), two Alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.

Figures
Products