Bioactive tetrahydrofuran lignans from Peperomia dindygulensis

J Nat Prod. 2005 Nov;68(11):1656-60. doi: 10.1021/np050283e.

Jian-lin Wu ¹, Na Li, Toshiaki Hasegawa, Jun-ichi Sakai, Saori Kakuta, Wanxia Tang, Seiko Oka, Miwa Kiuchi, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando

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Affiliation

1 Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Niigata 950-2181, Japan.

PMID: 16309318 DOI: 10.1021/np050283e

Abstract

Five new tetrahydrofuran Lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments.

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