2. Academic Validation
  3. Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996

Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996

  • J Nat Prod. 2005 Nov;68(11):1674-6. doi: 10.1021/np0502286.
Vatcharin Rukachaisirikul 1,  Chittreeya Tansakul,  Saowanit Saithong,  Chaveng Pakawatchai,  Masahiko Isaka,  Rapheephat Suvannakad
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. vatcharin.r@psu.ac.th
PMID: 16309322 DOI: 10.1021/np0502286
Abstract

Two new hirsutane Sesquiterpenes, connatusins A (1) and B (2), were isolated from the fungus Lentinus connatus BCC 8996. The structures, closely related to hypnophilin, were elucidated on the basis of the spectroscopic data. An X-ray analysis was performed to confirm the structure of 1. Six known compounds were also obtained. Panepoxydone (5), panepoxydione (6), and dihydrohypnophilin (8) exhibited significant antimalarial and cytotoxic activities.

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