2. Academic Validation
  3. Cytotoxic prenylflavonoids from Artocarpus elasticus

Cytotoxic prenylflavonoids from Artocarpus elasticus

  • J Nat Prod. 2005 Nov;68(11):1692-5. doi: 10.1021/np050287j.
Horng-Huey Ko 1,  Yi-Huang Lu,  Sheng-Zehn Yang,  Shen-Jeu Won,  Chun-Nan Lin
Affiliations

Affiliation

  • 1 School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PMID: 16309328 DOI: 10.1021/np050287j
Abstract

Five new prenylated Flavonoids, artelastoheterol (1), artelasticinol (2), cycloartelastoxanthone (3), artelastoxanthone (4), and cycloartelastoxanthendiol (5), along with five known compounds, were isolated from the root bark of Artocarpus elasticus. The structures of 1-5 were elucidated by spectroscopic methods and through comparison with data reported in the literature. The previously known compound artonol A (6) exhibited cytotoxic activity against the A549 human Cancer cell line, with an ED50 value of 1.1 microg/mL.

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