2. Academic Validation
  3. Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds

  • Org Biomol Chem. 2005 Dec 21;3(24):4392-4. doi: 10.1039/b513145f.
Hirokazu Tamamura 1,  Ai Esaka,  Teppei Ogawa,  Takanobu Araki,  Satoshi Ueda,  Zixuan Wang,  John O Trent,  Hiroshi Tsutsumi,  Hiroyuki Masuno,  Hideki Nakashima,  Naoki Yamamoto,  Stephen C Peiper,  Akira Otaka,  Nobutaka Fujii
Affiliations

Affiliation

  • 1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. tamamura.mr@tmd.ac.jp
PMID: 16327900 DOI: 10.1039/b513145f
Abstract

Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.

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