2. Academic Validation
  3. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

  • Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5. doi: 10.1016/j.bmcl.2005.12.002.
Jeremy L Clark 1,  J Christian Mason,  Laurent Hollecker,  Lieven J Stuyver,  Phillip M Tharnish,  Tamara R McBrayer,  Michael J Otto,  Phillip A Furman,  Raymond F Schinazi,  Kyoichi A Watanabe
Affiliations

Affiliation

  • 1 Pharmasset Inc., 1860 Montreal Road, Tucker, GA 30084, USA. j.clark@sri.org
PMID: 16368235 DOI: 10.1016/j.bmcl.2005.12.002
Abstract

A series of purine nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing a 2-amino group on the purine base reduced the levels of HCV RNA in a subgenomic replicon assay.

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