2. Academic Validation
  3. Antiviral Terpenoid Constituents of Ganoderma pfeifferi

Antiviral Terpenoid Constituents of Ganoderma pfeifferi

  • J Nat Prod. 2005 Dec;68(12):1728-31. doi: 10.1021/np0501886.
Timo H J Niedermeyer 1,  Ulrike Lindequist,  Renate Mentel,  Dirk Gördes,  Enrico Schmidt,  Kerstin Thurow,  Michael Lalk
Affiliations

Affiliation

  • 1 Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.
PMID: 16378363 DOI: 10.1021/np0501886
Abstract

Four sterols and 10 Triterpenes were isolated from the fruiting bodies of Ganoderma pfeifferi, including the three new Triterpenes 3,7,11-trioxo-5alpha-lanosta-8,24-diene-26-al (lucialdehyde D, 1), 5alpha-lanosta-8,24-diene-26-hydroxy-3,7-dione (ganoderone A, 2), and 5alpha-lanosta-8-ene-24,25-epoxy-26-hydroxy-3,7-dione (ganoderone C, 3). The structures of 1-3 were determined on the basis of spectroscopic evidence. Antibacterial, Antifungal, and Antiviral activity were studied for some of the isolated compounds. Ganoderone A (2), lucialdehyde B (4), and ergosta-7,22-dien-3beta-ol (7) were found to exhibit potent inhibitory activity against herpes simplex virus.

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