2. Academic Validation
  3. Organometallic enantiomeric scaffolding: organometallic chirons. Total synthesis of (-)-Bao Gong Teng A by a molybdenum-mediated [5 + 2] cycloaddition

Organometallic enantiomeric scaffolding: organometallic chirons. Total synthesis of (-)-Bao Gong Teng A by a molybdenum-mediated [5 + 2] cycloaddition

  • J Am Chem Soc. 2006 Jan 18;128(2):465-72. doi: 10.1021/ja055623x.
Yongqiang Zhang 1,  Lanny S Liebeskind
Affiliations

Affiliation

  • 1 Sanford S. Atwood Chemistry Center, Emory University, Atlanta, Georgia 30322, USA.
PMID: 16402833 DOI: 10.1021/ja055623x
Abstract

Bao Gong Teng A, an optically active tropane alkaloid with hypotensive and miotic activity isolated from the Chinese herb Erycibe obtusifolia Benth, was synthesized by an "organometallic chiron" strategy in which single enantiomers of TpMo(CO)(2)(eta(3)-pyridinyl) complexes are produced in quantity and then elaborated easily and efficiently to generate, after demetalation, highly enantiopure advanced synthetic intermediates possessing the tropane core.

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