2. Academic Validation
  3. Low molecular weight indole fragments as IMPDH inhibitors

Low molecular weight indole fragments as IMPDH inhibitors

  • Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. doi: 10.1016/j.bmcl.2006.01.089.
Rebekah E Beevers 1,  George M Buckley,  Natasha Davies,  Joanne L Fraser,  Francis C Galvin,  Duncan R Hannah,  Alan F Haughan,  Kerry Jenkins,  Stephen R Mack,  William R Pitt,  Andrew J Ratcliffe,  Marianna D Richard,  Verity Sabin,  Andrew Sharpe,  Sophie C Williams
Affiliations

Affiliation

  • 1 UCB Celltech, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
PMID: 16483769 DOI: 10.1016/j.bmcl.2006.01.089
Abstract

The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.

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