2. Academic Validation
  3. A photoreactive analogue of the immunosuppressant FTY720

A photoreactive analogue of the immunosuppressant FTY720

  • J Org Chem. 2006 Mar 3;71(5):2200-2. doi: 10.1021/jo0526237.
Chaode Sun 1,  Robert Bittman
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York 11367-1597, USA.
PMID: 16497020 DOI: 10.1021/jo0526237
Abstract

An azido group was incorporated into the immunomodulatory agent FTY720, accomplishing the first synthesis of a photoactivatable analogue of this ligand (2) in 9 steps from 2-(4-hydroxyphenyl)ethanol and in 34% overall yield. The key steps are formation of a primary amine at a quaternary center of aniline derivative 13 followed by selective diazotization of the arylamine.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-134976
    FTY720 Photoactivatable Analogue