2. Academic Validation
  3. Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrica

Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrica

  • J Nat Prod. 2006 Feb;69(2):290-1. doi: 10.1021/np0503808.
Jeong Seon Yoon 1,  Mi Kyeong Lee,  Sang Hyun Sung,  Young Choong Kim
Affiliations

Affiliation

  • 1 College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.
PMID: 16499335 DOI: 10.1021/np0503808
Abstract

Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.

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