2. Academic Validation
  3. Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus

Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus

  • J Nat Prod. 2006 Feb;69(2):295-8. doi: 10.1021/np0504513.
Laura Casu 1,  Leonardo Bonsignore,  Manuela Pinna,  Mariano Casu,  Costantino Floris,  Jürg Gertsch,  Filippo Cottiglia
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.
PMID: 16499337 DOI: 10.1021/np0504513
Abstract

Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced Apoptosis in HL-60 cells with corresponding IC(50) values ranging from 4 to 6 microM.

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