2. Academic Validation
  3. In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols

In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols

  • J Agric Food Chem. 2006 Mar 8;54(5):1646-50. doi: 10.1021/jf052486e.
Kirsti Parikka 1,  Ian R Rowland,  Robert W Welch,  Kristiina Wähälä
Affiliations

Affiliation

  • 1 Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014 Helsinki, Finland. kirsti.parikka@helsinki.fi
PMID: 16506814 DOI: 10.1021/jf052486e
Abstract

Incubation with 5-n-alkylresorcinols (chain lengths C15:0, C17:0, C19:0, C21:0, and C23:0) increased the self-protection capacity of HT29 human colon Cancer cells against DNA damage induced by hydrogen peroxide and genotoxic fecal water samples using comet assay (single-cell gel electrophoresis assay). The alkylresorcinols did not exert potent antioxidant activity in the FRAP (ferric reduction ability of plasma) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical assays. However they were able to significantly inhibit copper-mediated oxidation of human LDL (low-density lipoprotein) in vitro, and pentadecylresorcinol at 25 micromol/L increased lag time by 65 min. The results show that alkylresorcinols have antigenotoxic and antioxidant activity under in vitro conditions.

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