2. Academic Validation
  3. A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity

A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity

  • Bioorg Med Chem Lett. 2006 Jun 15;16(12):3224-8. doi: 10.1016/j.bmcl.2006.03.043.
Xuesen Fan 1,  Xinying Zhang,  Longhu Zhou,  Kathy A Keith,  Earl R Kern,  Paul F Torrence
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011, USA.
PMID: 16603351 DOI: 10.1016/j.bmcl.2006.03.043
Abstract

Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the Other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro Antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.

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