2. Academic Validation
  3. Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands

  • Bioorg Med Chem Lett. 2006 Jun 15;16(12):3213-8. doi: 10.1016/j.bmcl.2006.03.075.
Masahiko Kainuma 1,  Jun-ichi Kasuga,  Shinnosuke Hosoda,  Ken-ichi Wakabayashi,  Aya Tanatani,  Kazuo Nagasawa,  Hiroyuki Miyachi,  Makoto Makishima,  Yuichi Hashimoto
Affiliations

Affiliation

  • 1 Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
PMID: 16617018 DOI: 10.1016/j.bmcl.2006.03.075
Abstract

Novel, potent farnesoid X receptor (FXR) and Peroxisome Proliferator-activated Receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

Figures