2. Academic Validation
  3. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma

Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma

  • Int Immunopharmacol. 2006 Jun;6(6):978-86. doi: 10.1016/j.intimp.2006.01.010.
Sei-Ryang Oh 1,  Mee Young Lee,  Kyungseop Ahn,  Bo-Young Park,  Ok-Kyuoung Kwon,  Hyouk Joung,  Joongku Lee,  Doo-Young Kim,  Sangku Lee,  Joo Heon Kim,  Hyeong-Kyu Lee
Affiliations

Affiliation

  • 1 Innunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-333, South Korea.
PMID: 16644484 DOI: 10.1016/j.intimp.2006.01.010
Abstract

Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.

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