2. Academic Validation
  3. Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis

  • Planta Med. 2006 Jul;72(9):847-50. doi: 10.1055/s-2006-931606.
Enos Tangke Arung 1,  Kuniyoshi Shimizu,  Ryuichiro Kondo
Affiliations

Affiliation

  • 1 Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
PMID: 16732541 DOI: 10.1055/s-2006-931606
Abstract

Isoprenoid-substituted Flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting Tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-N2902
    Melanin Biosynthesis Inhibitor